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Ancient ‘relaxant-inflammatory’ response gets sponges moving


Sponges have neither neurons nor muscles, yet they move. EMBL Heidelberg scientists have revealed how they do this and what this tells us about the evolution of blood vessels



Volume changes of the sponge canal systems during spontaneous deflations of the sponge Spongilla lacustris, observed and quantified using a custom optical coherence microscope. Credit: Ling Wang, Anniek Stokkermans, Fabian Ruperti/EMBL. Source: Current Biology


Summary

  • Sponge movement is driven by ‘deflation’ of water canals inside the sponge body rather than, as assumed before, by contraction

  • This deflation is driven by the relaxation of stress fibres inside the cells lining the water canals and involves molecular signals similar to those that are involved in inflammation in vertebrates

  • This ‘relaxant-inflammatory’ response is also present in the blood vessels of humans and other vertebrates


Did you know that sponges can move? While not exactly the champions of underwater acrobatics, sponges exhibit coordinated movements — despite not having muscles or neurons. EMBL Heidelberg’s Arendt Group, in collaboration with the Savitski Team and the Prevedel Group, along with collaborators from the University of Heidelberg, and Yale University, has revealed surprising facts that not only shed light on sponge movement, but also on the evolution of blood vessels in humans and other animals.


“I was intrigued when I learned that sponges actually move and that the molecular and cellular basis of sponge movement was so far largely unknown,” said Fabian Ruperti, PhD student in the Arendt Group and first author of the study. “As a biochemist, I was excited to tackle this question by combining new tools such as functional proteomics with the world of non-model species.”


Sponge movement relies on a system of densely branched water canals inside their body. When some of the canals close and the water gets flushed out, the sponge makes a whole-body movement, which until now, was believed to be caused by contraction of the cells lining the canals. The new findings show that this movement has actually more to do with relaxation and ‘deflation’ of the water canals, akin to the deflation of a balloon.


To dive deeper into the molecular and cellular mechanism of the sponge deflation, the scientists used advanced microscopy, pharmacology, single-cell sequencing, and several new proteomics techniques. They saw that what gets the sponge moving is the relaxation of stress fibres inside the cells of the canals, which is in turn triggered by an evolutionarily ancient inflammation-like molecular mechanism. Notably, the very same mechanism also regulates the contraction of the blood vessels of humans and other vertebrates, an important determinant of blood pressure.


“We learn that responses such as vascular relaxation and inflammation are not restricted to us, but instead occur in our very remote cousins, the sponges,” said Group Leader Detlev Arendt. “These processes must have evolved in the context of a challenge that is relevant not only for us, but also for many other animals. That means, we can only understand the structure and function of these systems in the context of evolution.”


3D reconstruction of the deflation of the Spongilla lacustris  canal systems. The scientists were especially intrigued by the fractal nature of the heavily branching excurrent canals. Credit: Ling Wang, Anniek Stokkermans, Fabian Ruperti/EMBL. Source: Current Biology



Source article(s)

Ruperti F., et al.

Current Biology 4 January 2024

10.1016/j.cub.2023.12.021


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